MemoHoney ingredients: the six names on the label and the dose behind each

Arginine is the amino acid nitric oxide is made from, which is why it opens this list and why it appears twice on it. Swallowed on its own it has an awkward problem: a large share of an oral dose is broken down in the gut wall and the liver before it reaches the bloodstream, so plasma arginine rises less than the label on the tub suggests.

the 2026 arginine blood pressure meta-analysis pooled five randomised trials in 202 people using ambulatory monitoring and found 24-hour systolic pressure fell by about 4.2 mmHg and diastolic by about 3.0. That is a real effect and it is a blood pressure effect. The doses behind it run 6 to 9 grams a day.

Its safety file is worth knowing. the VINTAGE MI trial gave 3 grams three times a day, 9 grams daily, to people recovering from a heart attack, for six months. The trial was stopped: arginine did not improve vascular stiffness and more deaths occurred in the arginine group. The authors concluded it should not be recommended after a myocardial infarction. That finding is about a specific population at a pharmacological dose, and it is the reason anyone with heart disease should raise this capsule with their prescriber rather than assume an amino acid is inert.

Arginine bound to alpha-ketoglutarate at two parts to one. The pairing came out of the sports supplement market on the theory that the ketoglutarate half improves how much arginine survives to the bloodstream. Three human trials speak to it and all three measured the body, not the mind.

the AAKG performance trial gave 3,000 mg acutely before resistance exercise and found no improvement in muscular performance in either trained or untrained men. the seven-day AAKG blood flow study ran 12 grams a day for seven days and measured blood flow, plasma arginine, nitric oxide metabolites and asymmetric dimethylarginine after resistance exercise. the AAKG and HMB jump trial used 10 grams a day alongside 7.5 grams of HMB in young track and field athletes, and reported that the combination helped prevent a decline in jump performance across a training block.

Three grams acute, ten to twelve grams daily, and the endpoints are jump height, endurance and forearm blood flow. Nothing in that literature measures recall, attention or processing speed.

Citrulline is the better way to raise arginine, and that is not marketing. It bypasses the gut and liver breakdown that limits oral arginine, then the kidney converts it. the citrulline pharmacokinetic study is the study that established it: oral L-citrulline raised the area under the curve and peak plasma arginine in a dose-dependent way, and the highest arm, 3 grams twice a day, also lifted the trough concentration.

That makes the two citrulline rows the best-argued ingredients on this label. It also sets the scale: 6 grams a day, split, to move the marker the whole formula depends on.

the citrulline blood pressure review pooled citrulline supplementation and watermelon intake in middle-aged and older adults and found blood pressure came down overall. Again a vascular endpoint, again at gram-scale doses, and again not a memory endpoint.

The same amino acid bound to malic acid, which is the form the sports market standardised on. Whether the malate half adds anything has now been tested directly. the citrulline-versus-citrulline-malate trial gave 43 trained adults a placebo, 5.3 grams of citrulline, or 5.3 grams of citrulline with 2.7 grams of malate, 45 minutes before testing. Neither arm improved maximal neuromuscular performance, ballistic strength or strength endurance. The malate added nothing, and neither form added anything.

the six-week resistance training trial went longer, six weeks of 8 grams of L-citrulline or 12 grams of citrulline malate a day alongside resistance training. the flow-mediated dilation study tested 6 and 12 grams acutely against flow-mediated dilation in healthy young men: both doses raised serum citrulline, arginine and ornithine, and neither improved dilation. It also raised asymmetric and symmetric dimethylarginine, which are the molecules that inhibit nitric oxide synthase.

the 2026 citrulline malate meta-analysis is the current summary: thirty randomised trials, 644 participants, a small overall effect on exercise performance of g = 0.16, wide prediction intervals, and GRADE certainty rated low to very low. Reliable dosing and target populations, in the authors' own words, have not been established.

The only ingredient on this label with a published line to cognition, and the only one that works at a dose a capsule can carry. Niacin is a precursor to NAD and NADP, the coenzymes almost every cell uses to move electrons around, and severe deficiency produces pellagra, whose third classical symptom is dementia. a 2026 pellagra case report is a recent reminder that the cognitive part of that picture reverses when the vitamin is replaced.

the Chicago dietary niacin cohort is the cohort everyone cites. Among 3,718 Chicago residents with dietary data and repeated cognitive testing, people in the upper quintiles of total niacin intake had roughly a third of the risk of incident Alzheimer's disease of the lowest quintile, and food niacin tracked a slower annual rate of decline. It is observational, it is about diet rather than capsules, and it cannot show that adding niacin to an already adequate intake helps anyone.

Two things bound the enthusiasm. the HPS2-THRIVE safety report put 25,673 high-risk patients on extended-release niacin at 2 grams a day with laropiprant and found excess myopathy and liver signals; that is a pharmacological dose, far above anything a memory capsule carries, but it is why niacin is a vitamin with a safety file. And the 2024 niacin metabolite paper reported in Nature Medicine that 4PY, a terminal breakdown product of niacin, promotes vascular inflammation and tracks cardiovascular risk. Neither finding applies at dietary amounts. Both are reasons to know how much you are taking, which this label cannot tell you.

Beta-alanine is the rate-limiting half of carnosine, the dipeptide muscle uses to buffer acid during hard effort. the ISSN position stand on beta-alanine, the International Society of Sports Nutrition position stand, sets the effective protocol at 4 to 6 grams a day for at least four weeks and notes that the only commonly reported side effect is paraesthesia, the tingling that follows a large single dose, which divided 1.6-gram doses or a sustained-release form reduce.

the two-protocol carnosine loading study compared 6 grams a day for four weeks against 12 grams a day for two and measured the muscle carnosine each produced. the four-week kickboxing trial ran 6.4 grams a day for four weeks in trained kickboxers. the beta-alanine risk assessment is the systematic risk assessment, and it concluded that supplementation within the doses used in the available research is not associated with harm.

Every one of those endpoints is muscular. There is no human trial of beta-alanine for memory. The nearest thing in its family is the NEAT carnosine trial, which gave 2 grams of carnosine itself daily for up to twelve weeks and found a cognitive benefit restricted to the younger half of the sample. Different molecule, different dose, and a result that does not transfer.